bempedoic acid drug class

This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Bempedoic acid is used together with diet and other medicines to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL). Bempedoic acid is for use in adults with an inherited form of high cholesterol. • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. ... On Feb. 21, 2020, the Food and Drug Administration (FDA) provided approval for the use of bempedoic acid… Excipient information presented when available (limited, particularly for generics); consult specific product labeling. In general, bempedoic acid should be discontinued if pregnancy occurs. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate. Manufacturer1: Esperion Therapeutics . Bempedoic acid; Other brands: Nexletol. Consider therapy modification, Grazoprevir: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Grazoprevir. low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet. Nexlizet contains two medicines … Specifically, concentrations of elagolix may be increased. Avoid combination, Pravastatin: Bempedoic Acid may increase the serum concentration of Pravastatin. Follow all directions on your medicine label and package. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs … Oral: May be administered without regard to food. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in the cholesterol biosynthesis pathway. Store at room temperature away from moisture and heat. Copyright 1996-2021 Cerner Multum, Inc. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. Management: Decrease the eluxadoline dose to 75 mg twice daily if combined with OATP1B1/1B3 inhibitors and monitor patients for increased eluxadoline effects/toxicities. Davis Drug … Avoid combination, Elagolix: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Elagolix. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibition of cholesterol synthesis in the liver. Consider therapy modification, Voxilaprevir: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Voxilaprevir. Assess uric acid levels periodically as clinically indicated. pain in your back, shoulder, legs, or arms; cold symptoms such as stuffy nose, sneezing, sore throat. You may take bempedoic acid with or without food. Monitor lipid levels within 8 to 12 weeks of therapy initiation; signs/symptoms of hyperuricemia, assess uric acid levels as clinically indicated; signs/symptoms of tendon rupture (eg, joint pain, swelling, inflammation). Follow all directions on your prescription label and read all medication guides or instruction sheets. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibiting cholesterol synthesis in the liver. Tendon Rupture: Bempedoic acid … Consider discontinuing therapy if joint pain, swelling, or inflammation occurs; discontinue immediately if tendon rupture occurs. Avoid combination. There are no contraindications listed in the manufacturer's labeling. Bempedoic acid is first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor used once a day for reducing LDL cholesterol levels in statin-refractory patients. “Bempedoic acid (Esperion Therapeutics) is a first-in-class small molecule inhibitor of ATP citrate lyase, an enzyme upstream of HMG-CoA reductase in cholesterol … The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Follow your doctor's instructions about any restrictions on food, beverages, or activity. kidney disease (or if you are on dialysis); Bempedoic acid may harm an unborn baby. Hepatic; primarily through metabolism of the acyl glucuronide; reversibly converted by aldo-keto reductase enzyme to an active metabolite (ESP15228), which is also converted to a glucuronide conjugate. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Unable to move or put weight on a joint, • Hear or feel a snap or pop in a joint, • Tendon inflammation or rupture like pain, bruising, or swelling in the back of the ankle, shoulder, hand, or other joints. The drug, bempedoic acid, is the first in a new class of drugs to treat low-density-lipoprotein cholesterol, also called “bad” cholesterol, which causes the buildup of fatty deposits … Bempedoic acid and ezetimibe is a combination medicine that is used to lower blood levels of "bad" cholesterol (low-density … Available for Android and iOS devices. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Bempedoic acid is a novel class of nonstatin therapy that targets hepatic cholesterol synthesis and has demonstrated significant LDL-C lowering ability as monotherapy … Drug Name Active Ingredients Strength Dosage Form/Route Marketing Status TE Code RLD RS; NEXLETOL: BEMPEDOIC ACID: 180MG: TABLET;ORAL: Prescription: None Yes: Yes: … A new class of oral cholesterol-lowering drug could help patients unable to take statins due to side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Talk to your doctor if you have questions. Our objective was to estimate its average effect on … Side Effects; During Pregnancy; Drug Interactions; En Español; Drug class: miscellaneous antihyperlipidemic agents; Consumer resources. Stop taking bempedoic acid and seek medical attention right away if you have signs of tendon rupture: sudden pain, swelling, bruising, or tenderness; or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions). Feces (30%; <5% as unchanged drug); urine (<5% as unchanged drug; ~70% of total dose as bempedoic acid and metabolites). Heterozygous familial hypercholesterolemia: Treatment of heterozygous familial hypercholesterolemia, as an adjunct to diet and maximally tolerated statin therapy, in adult patients who require additional lowering of LDL-C. NEXLETOL TM (bempedoic acid) Tablet NEXLETOL is a first-in-class ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C by reducing cholesterol biosynthesis and up … Bempedoic acid and its fixed combination drug product with ezetimibe were approved in the European Union and the United States earlier this year with different labels … Consider therapy modification, Revefenacin: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase serum concentrations of the active metabolite(s) of Revefenacin. Bempedoic acid is a first-in-class oral adenosine triphosphate (ATP) citrate lyase inhibitor being evaluated as an additional treatment option for high-risk patients requiring further reduction in LDL-C. Bempedoic acid … ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol bi… You may report side effects to FDA at 1-800-FDA-1088. It was developed by … Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. • Hyperuricemia: Increases in serum uric acid have occurred, usually within the first 4 weeks of treatment initiation, and persisted throughout treatment. Bempedoic acid belongs to a group of drugs called adenosine triphosphate-citrate lyase inhibitors. Consider alternative therapy in patients with a history of tendon disorders or tendon rupture. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Bempedoic acid is a non-statin, targeted therapy designed to primarily work in the liver to inhibit cholesterol biosynthesis. Avoid combination, Elagolix, Estradiol, and Norethindrone: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Elagolix, Estradiol, and Norethindrone. Avoid combination, Eluxadoline: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Eluxadoline. We comply with the HONcode standard for trustworthy health information -, heterozygous familial hypercholesterolemia, Drug class: miscellaneous antihyperlipidemic agents. How … Available for Android and iOS devices. atorvastatin, simvastatin, Lipitor, rosuvastatin, Crestor, ezetimibe. Last updated on July 17, 2020. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in the cholesterol biosynthesis pathway. Tell your doctor right away if you become pregnant. The findings come from the largest study to date to test the effectiveness and safety of bempedoic acid… We comply with the HONcode standard for trustworthy health information -, Drug class: miscellaneous antihyperlipidemic agents, Antilipemic Agent, Adenosine Triphosphate-Citrate Lyase (ACL) Inhibitor. >10%: Endocrine & metabolic: Gout (2% [placebo: 0.4%]; with prior gout history: 11% [placebo: 2%]), hyperuricemia (4% to 26% [placebo: 1% to 10%]), Cardiovascular: Atrial fibrillation (2%), increased serum creatine kinase (1%), Gastrointestinal: Abdominal distress (≤3%), abdominal pain (≤3%), Genitourinary: Benign prostatic hyperplasia (1%), Hematologic & oncologic: Anemia (3%), leukopenia (9%), thrombocythemia (10%), Hepatic: Increased liver enzymes (2%), increased serum aspartate aminotransferase (1%), Neuromuscular & skeletal: Back pain (3%), limb pain (3%), muscle spasm (4%), Renal: Increased blood urea nitrogen (4%), increased serum creatinine (2%), Respiratory: Upper respiratory tract infection (5%), <1%: Neuromuscular & skeletal: Rupture of tendon (placebo: 0%). What is bempedoic acid and ezetimibe? Nursing Central is an award-winning, complete mobile solution for nurses and students. Avoid combination, Simvastatin: Bempedoic Acid may increase the serum concentration of Simvastatin. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Limitations of use: The effect of bempedoic acid on cardiovascular morbidity and mortality has not been determined. It works by blocking the production of cholesterol in the liver. The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. What is bempedoic acid? Professional resources. Usual Adult Dose for Heterozygous Familial Hypercholesterolemia: 180 mg orally once a day Comments:-This drug should be given with maximally tolerated statin therapy. Bempedoic acid may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the arm, shoulder, or Achilles' tendon of the heel. Other drugs may affect bempedoic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Nexletol (bempedoic acid) is a first-in-class, adenosine triphosphate-citrate lyase (ACL) inhibitor for the treatment of adults with heterozygous familial hypercholesterolemia or established … Medically reviewed by Drugs.com. More about bempedoic acid. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. -Lipid levels should be checked within 8 to 12 weeks of treatment initiation. Use the medicine exactly as directed. Refer to adult dosing. Generic Name: bempedoic acid (BEM pe DOE ik AS id)Brand Name: NexletolDosage Forms: oral tablet (180 mg). Assess uric acid levels periodically as clinically indicated. Usual Adult Dose for Cardiovascular Risk Reduction: Tell your doctor about all other cholesterol medicines you use, especially: This list is not complete. Note: This is not a comprehensive list of all side effects. Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Brand Name: Nexletol Generic Name: bempedoic acid . Bempedoic acid is first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor used once a day for reducing LDL cholesterol levels in statin-refractory patients. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. ACSVL1 is expressed primarily in the liver. Learn about bempedoic acid and the CLEAR program. All drugs may cause side effects. Bempedoic acid is used together with diet and other medicines to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL). Bempedoic acid and its active metabolite, ESP15228, require coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA and ESP1522… This is not a complete list of side effects and others may occur. It is not known if bempedoic acid can lower the risk of complications related to high cholesterol (such as heart problems, heart attack, stroke, or death). However, many people have no side effects or only have minor side effects. You should not breastfeed while using bempedoic acid. • Tendon rupture: Tendon rupture or injury has occurred within weeks to months of treatment initiation; increased risk in patients >60 years of age, those taking corticosteroid or fluoroquinolone drugs, and patients with renal failure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Call your doctor for medical advice about side effects. Bempedoic acid is in a class of medications called adenosine triphosphate-citrate lyase (ACL) inhibitors. “Bempedoic acid is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers LDL-C by inhibiting cholesterol synthesis in the liver. Tendon problems may be more likely in certain people (older adults, people with kidney disease, or people who take steroid medicine or certain antibiotics. Version: 1.01. atorvastatin, simvastatin, Lipitor, rosuvastatin, Crestor, ezetimibe. Not all possible drug interactions are listed here. This can happen within days or months after you start taking bempedoic acid. Nexletol (bempedoic acid) is a member of the miscellaneous antihyperlipidemic agents drug class and is commonly used for High Cholesterol - Familial Heterozygous. Bempedoic acid is a small molecule drug intended to block cholesterol synthesis in the liver, similar to the approach of statins. Based on the mechanism of action, in utero exposure to bempedoic acid may cause fetal harm. Data are not available regarding drug … The evaluation of ICER will be ongoing over the next … But statins are also thought to affect cholesterol … ICER had previously announced in July of last year that evaluating bempedoic acid was in their potential plans for 2020. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. Bempedoic acid and its active metabolite, ESP15228, require coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA and ESP15228-CoA, respectively. Atherosclerotic cardiovascular disease, established: Treatment of established atherosclerotic cardiovascular disease, as an adjunct to diet and maximally tolerated statin therapy, in adult patients who require additional lowering of low-density lipoprotein cholesterol (LDL-C).

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